Efficacy of zinc supplements in reducing relapses in steroid-sensitive nephrotic syndrome.

Efficacy of zinc
supplements in reducing relapses in steroid-sensitive nephrotic syndrome.

Arun
S, Bhatnagar
S, Menon
S, Saini
S, Hari
P, Bagga
A.

Division of Nephrology, Department of Pediatrics, All
India Institute of Medical Sciences, New
Delhi, India.

Relapses in steroid-sensitive
nephrotic syndrome (SSNS) often follow infections of the respiratory or
gastrointestinal tract. Based on data that zinc supplements reduce the risk of
infections, we examined the efficacy of such supplements in reducing relapse
rates in these patients. Eighty-one patients with SSNS (1-16 years old) were
stratified into frequent (n = 52) and infrequent (n = 29) relapsers and
randomized to receive 12-months of therapy with the recommended dietary allowance
of zinc (10 mg/day) (n = 40) or placebo (n = 41). Patients with frequent
relapses also received long-term, alternate-day prednisolone. Subjects
receiving zinc showed a 20% lower frequency of relapses, with 44.7% of the
patients having sustained remission compared to 27.5% in the placebo group (P
> 0.05). Patients with frequent relapses receiving zinc showed a 28%
reduction in relapse rates and a significantly higher likelihood of sustained
remission (P = 0.02). Findings from this double blind, randomized study suggest
that zinc supplementation results in trends towards remission and reduced
relapses, especially in patients with frequent relapses. Prospective,
adequately powered studies are required for confirmation of these findings.

PMID: 19347367 [PubMed - as supplied by publisher]

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Efficacy of zinc supplements in reducing relapses in steroid-sensitive nephrotic syndrome. Dralatwani2gif

Thanks Dr.Salim Al-Atwani for Breif nice useful issue my best wishes
خالص شكري وتقديري لك د- سالم العطواني موضوع مختصر ومفيد جدا لدينا كثير من المرضى يعانون من هذا المرض-تناذر الكليتين نتمنى أن يستفيدوا من علاج الزنك تقبل تحياتي

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خالص شكري وتقديري د-عبد الهادي الجريصي </p>
<p> Efficacy of zinc supplements in reducing relapses in steroid-sensitive nephrotic syndrome. HaveANicedayRose

Efficacy of zinc supplements in reducing relapses in steroid-sensitive nephrotic syndrome. HaveANicedayRose

</p>

كثير من المرضى ممن يعانون من تناذر الكليتين لايجدون العلاج الشافي السريع كي ينقضهم من الامهم لذا اذا كان هذا العلاج مفيد كما هو مذكور فلايسعنس الا ان اقول الله محييك يادكتور سالم وان شاء الله نسير الى الامام في الحصول على كل ماهو جديد للمساعده في شفاء المرضى الذين يملؤن مستشفاياتنا وشكراً

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» المتلازمة المرضية الكلوية - تناذر الكليتين Nephrotic Syndrome
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